| Pick | Team | Pos | Player | School |
| 1 | St. Louis Rams | TE | Fendi Onobun | Houston |
| Former Arizona basketball player with limited experience but excellent physical tools including a sub 4.5 40. |
| 2 | Atlanta Falcons (from Lions) | S | Shann Schillinger | Montana |
| 4 year starter and All-Big Sky performer. Sure tackler with solid coverage skills. Very athletic. |
| 3 | Tampa Bay Buccaneers | P | Brent Bowden | Virginia Tech |
| Need pick. Possesses a strong leg and does a good job of pinning teams inside the 20. |
| 4 | San Francisco 49ers (from Chiefs via Dolphins and Chargers) | RB | Anthony Dixon | Mississippi St. |
| Big powerful back who led SEC in rushing yards per game (126.5)in 2009. |
| 5 | Washington Redskins (from Redskins via Dolphins) | FB | Dennis Morris | Louisiana Tech |
| H-back type, 2009 First Team All-WAC TE after accumulating 38 rec, 623 yds and 12 TDs. |
| 6 | Carolina Panthers (from Raiders) | DE | Greg Hardy | Mississippi |
| Natural pass rusher who had 10 sacks and 18.5 TFL in 2007. Battled injuries in 2008-2009 accumulating 13.5 sacks in limited action. Has work ethic concerns. |
| 7 | Tennessee Titans (from Seahawks) | QB | Rusty Smith | Fla. Atlantic |
| Developmental quarterback with good size and arm strength. Needs to improve his accuracy. |
| 8 | Cleveland Browns | WR | Carlton Mitchell | South Fla. |
| Tall, fast receiver with big play ability who averaged 17.7 ypc in 2009. Questionable hands. |
| 9 | Buffalo Bills | DE/34LB | Arthur Moats | James Madison |
| Athletic 3-4 OLB prospect. CAA Defensive POY and Buchanan Award winner in 2009 with 90 tackles, 23.5 TFL, 11 sacks. |
| 10 | Dallas Cowboys (from Dolphins) | OT | Sam Young | Notre Dame |
| 4 year starter at Notre Dame, Sam Young has good size and is a powerful run blocker. A right tackle only who struggles vs. speed rushers. |
| 11 | Jacksonville Jaguars | RB | Deji Karim | Southern Illinois |
| Undersized speed back who had gained 1,694 yards while averaging 7.1 ypc in 2009. Has return skills. |
| 12 | Chicago Bears | QB | Dan LeFevour | Central Mich. |
| Athletic 4 year starter with underrated passing skills. A good fit for Mike Martz's offense. |
| 13 | San Francisco 49ers | TE | Nate Byham | Pittsburgh |
| Limited receiver but one of the best blocking tight ends in this year's draft class. |
| 14 | Denver Broncos | C | Eric Olsen | Notre Dame |
| Tough, versatile lineman who will challenge for a backup spot at center and guard. |
| 15 | New York Giants | DE | Adrian Tracy | William & Mary |
| Sleeper pass rusher. Two time all-CAA selection who had 22 TFL and 12 sacks in 2009. |
| 16 | Seattle Seahawks (from Titans) | TE | Anthony McCoy | Southern California |
| Pete Carroll is re-united with a former Trojan. All-around tight end who averaged 20.8 ypc in 2009. Has character concerns including failed drug test. |
| 17 | Cleveland Browns (from Panthers) | DE | Clifton Geathers | South Carolina |
| Inconsistent performer but a good athlete with rare size and length for a defensive end. A 5 technique prospect. |
| 18 | Houston Texans | G | Shelley Smith | Colorado State |
| Athletic guard who is a good fit for the Texans zone-blocking scheme. |
| 19 | Pittsburgh Steelers | RB | Jonathan Dwyer | Georgia Tech |
| Big, powerful runner who must transition for a flex option offense. A poor man's Jerome Bettis. Had 1,395 yards in 2008 and 2009. Slid due to medical concerns. |
| 20 | St. Louis Rams (from Falcons) | DE/34LB | Eugene Sims | West Texas A&M |
| Long, lean defensive end with potential as a pass rusher. Good enough athlete to possibly move to SAM linebacker. |
| 21 | Oakland Raiders (from Patriots) | OLB | Travis Goethel | Arizona St. |
| Hard working versatile linebacker. Not the off the charts athlete you expect from an Al Davis selection. |
| 22 | Cincinnati Bengals | WR | Dezmon Briscoe | Kansas |
| Tall receiver known for making tough catches in traffic. Had 1,337 receiving yards and 9 TDs in 2009. Has character concerns. |
| 23 | Buffalo Bills (from Eagles) | DE/34LB | Danny Batten | South Dakota State |
| Hard working 3-4 outside linebacker prospect. Had 9 sacks and 17 TFL in 2009. |
| 24 | Green Bay Packers | RB | James Starks | Buffalo |
| Dual threat back who had 1,694 rushing/receiving yards in 2008. Missed 2009 with a labral tear. |
| 25 | Baltimore Ravens | OT | Ramon Harewood | Morehouse |
| Looks the part at at 6-7 360 lbs. Raw developmental prospect with potential as a right tackle or right guard. |
| 26 | Pittsburgh Steelers (from Cardinals) | WR | Antonio Brown | Central Mich. |
| One of the draft's top sleeper prospects. Playmaking slot receiving with tremendous run after catch ability and a dangerous kick returner. |
| 27 | Dallas Cowboys | CB | Jamar Wall | Texas Tech |
| Instinctive, athletic cornerback prospect. Has good ball skills and will challenge for a backup corner job in a thin Cowboy secondary. |
| 28 | Houston Texans (from Chargers) | RB | Trindon Holliday | LSU |
| Undersized but lightning quick kick returner. Limited experience as a RB/WR. |
| 29 | Carolina Panthers (from Jets) | WR | David Gettis | Baylor |
| Good combination of size, speed and athleticism but needs to catch the ball cleanly and show special teams ability to make the Panthers roster. |
| 30 | Minnesota Vikings | QB | Joe Webb | UAB |
| College quarterback who will be asked to play WR/Wildcat/ST role. Threw for 2,000 yards and rushed for 1,000 yards in 2008 and 2009. |
| 31 | Philadelphia Eagles (from Colts) | RB | Charles Scott | LSU |
| Powerful runner who had 18 TDs in 2008 but struggled with injuries and inconsistency in 2009. |
| 32 | Arizona Cardinals (from Saints) | CB | Jorrick Calvin | Troy |
| Special teams standout who was academically ineligible in 2009. |
| 33 | Carolina Panthers (Compensation Pick) | S | Jordan Pugh | Texas A&M |
| Rangy free safety had 3 INTs and 9 PBU in 2009. Has starting experience at corner and safety. |
| 34 | Jacksonville Jaguars (Compensation Pick) | CB | Scotty McGee | James Madison |
| Dynamic return specialist. Not expected to have much of an impact at cornerback. |
| 35 | Carolina Panthers (Compensation Pick) | QB | Tony Pike | Cincinnati |
| Tall pocket passer who needs to bulk up and adjust to a pro style offense. Will battle for the #3 QB job. |
| 36 | New England Patriots (Compensation Pick) | C | Ted Larsen | North Carolina State |
| Former defensive tackle, who switched to center in 2008. Hard worker with above average athleticism. Has upside if given a chance to develop. |
| 37 | San Francisco 49ers (Compensation Pick) | WR | Kyle Williams | Arizona State |
| Speedy receiver/returner. Dangerous runner in the open field. |
| 38 | Tennessee Titans (Compensation Pick) | S | Myron Rolle | Florida State |
| Rhodes scholar. Instinctive strong safety with excels versus the run but has limited range in coverage. |